Northern Dimension Partnership in Public Health and Social Well-being

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Northern Dimension Antibiotic Resistance Study (NoDARS)

Project title Northern Dimension Antibiotic Resistance Study (NoDARS)
Database Data manually inserted in the NDPHS Database
ID in the source database 1468
Thematic area Antimicrobial Resistance
Topic Antibiotic resistance levels and the penetration of antibiotic resistance in the healthy population
Project geographical area
  • Finland
  • Germany
  • Latvia
  • Poland
  • Russia
  • Sweden
Substate level / administrative units /regions no data
Lead partner (organisation) Northern Dimension Partnership in Public Health and Social Well-being (NDPHS) Secretariat
Lead partner (owner or/and project manager) NDPHS Secretariat
Partner organisations
  • Institute of Antimicrobial Chemotherapy of Smolensk State Medical University (Russian Federation)
  • Institute of Occupational Medicine and Environmental Health (Poland)
  • Pauls Stradins Clinical University Hospital (Latvia)
  • The Public Health Agency of Sweden
  • Robert Koch Institute (Germany)
  • University of Turku (Finland)
Start date 2014-10-01
End date 2017-09-30
Duration (months) 36
Target audience The main target audience are health care professionals and providers as well as authorities and policy makers. However, the general public can also profit from the study results.
Summary The primary aim of the NoDARS project was to gain new knowledge regarding resistance levels in uncomplicated urinary tract infections (UTI) that normally are not subjected to microbiological analysis; to look for specific resistance determinants in the normal flora of healthy individuals and use these results to assess and improve existing guidelines for antibiotic treatment of uncomplicated UTIs as well as to evaluate existing AMR-strategies in the countries that participated in the study. Altogether the results of the study will be informing the empirical treatment of common urinary tract infections. It also brought important information on the penetration of resistance in the population. Different AMR-strategies applied in the participating countries were evaluated in the context of evidence informed policy making.
Background Currently, guidelines for uncomplicated urinary tract infections are generally based on antibiotic resistance levels determined from isolates in severely ill patients with invasive infections. However, high resistance levels correlate with a low number of samples per inhabitants indicating that the denominator varies greatly between the participating countries, which most likely biases the results and leads to an overestimation of AST-levels in countries with low denominators. This, in turn, pushes the use of unnecessary broad spectrum antibiotics, which causes the development and dissemination of antibiotic resistance.
Objectives 1. To assess if current national guidelines for treatment of uncomplicated infections, in the respective states, are based on data that are overestimating antibiotic resistance and if so provide advice to relevant authorities and professional societies in order to facilitate and promote revision of such guidelines. 2. Strengthening of capacities regarding methodology in antibiotic susceptibility testing and thereby support ongoing global surveillance initiatives from the WHO and regional initiatives such as by the ECDC and WHO-Europe.
Specific objectives/indicators 1. Identify and establish comparable sentinel sites in each of the states to assess true resistance levels in Escherichia coli causing uncomplicated urinary tract infections (UTIs). 2. Assess the penetration of antibiotic resistance in society and identify specific resistance determinants among the normal flora of healthy individuals tested at the participating laboratories. 3. Assess and improve existing guidelines for the treatment of uncomplicated UTIs. 4. Evaluate and suggest improvements for existing AMR strategies.
Results The project provided new useful information on the levels of antibiotic resistance in the countries participating in the project (Finland, Germany, Latvia, Poland, Russia, Sweden). NoDARS provided large and unique collections of E.coli isolates from uncomplicated UTIs that gives new insight into the resistance in one of the most under-sampled but at the same time common infections worldwide. The study shows that resistance patterns vary significantly among the partner countries. The NoDARS data also represents populations that are not normally included in surveillance of AMR, which contributes to raising the impact and interest in these groups. A major strength of the NoDARS project was the involvement of countries with different antimicrobial resistance situations, health care system organization and antimicrobial stewardship policies. Especially the perspective of Russia is important and often lacking in similar studies.
Total foreseen budget EUR 430,000
Total implementation costs
(for completed projects, if available)
EUR 414,000
Conversion to € was done on
(according to the relevant
exchange rate at
Infoeuro Monthly Files)
no data
Financing agencies / organisations
Project's URL / project's website no data
Papers associated with this project no data
Further information no data
Last posted: on 2018-04-06 at 16:07:46

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